$PBYI is one of biggest losers #stocks today. read more:

Puma Biotechnology Inc Common S (symbol: PBYI) was one of the worst losers
of the trading day today (2016-10-06), losing -9.02%. The number of shares
that changed hands was 1,180,769, or about 1 times the average daily volume
in the stock.
The closing price was $59.71, amounting to a market cap of $1,940,000,000,
about -37.1% off the highest price in the last 12 months. The stock has
been trading at a range between $19.74 and $94.93.
PBYI is in the Major Pharmaceuticals industry, part of the Health Care
sector.