$PBYI is one of biggest losers #stocks today. read more:

Puma Biotechnology Inc Common S (symbol: PBYI) was one of the worst losers
of the trading day today (2016-03-29), losing -21.06%. The number of shares
that changed hands was 4,164,664, or about 6 times the average daily volume
in the stock.
The closing price was $27.92, amounting to a market cap of $907,010,000,
about -88.6% off the highest price in the last 12 months. The stock has
been trading at a range between $25.2 and $244.9.
PBYI is in the Major Pharmaceuticals industry, part of the Health Care
sector.