$PBYI is one of biggest losers #stocks today. read more:

Puma Biotechnology Inc Common S (symbol: PBYI) was one of the worst losers
of the trading day today (2016-10-19), losing -18.9%. The number of shares
that changed hands was 4,128,531, or about 4 times the average daily volume
in the stock.
The closing price was $42.7, amounting to a market cap of $1,390,000,000,
about -55.02% off the highest price in the last 12 months. The stock has
been trading at a range between $19.74 and $94.93.
PBYI is in the Major Pharmaceuticals industry, part of the Health Care
sector.