$PBYI is one of biggest losers #stocks today. read more:

Puma Biotechnology Inc Common S (symbol: PBYI) was one of the worst losers
of the trading day today (2016-03-23), losing -13.7%. The number of shares
that changed hands was 837,038, or about 1 times the average daily volume
in the stock.
The closing price was $36.8, amounting to a market cap of $1,200,000,000,
about -84.97% off the highest price in the last 12 months. The stock has
been trading at a range between $34.71 and $244.9.
PBYI is in the Major Pharmaceuticals industry, part of the Health Care
sector.