$PBYI is one of biggest losers #stocks today. read more:

Puma Biotechnology Inc Common S (symbol: PBYI) was one of the worst losers
of the trading day today (2016-01-13), losing -13.73%. The number of shares
that changed hands was 1,142,396, or about 1 times the average daily volume
in the stock.
The closing price was $47.8, amounting to a market cap of $1,550,000,000,
about -81.1% off the highest price in the last 12 months. The stock has
been trading at a range between $47.48 and $252.92.
PBYI is in the Major Pharmaceuticals industry, part of the Health Care
sector.