$AGIO is one of biggest losers #stocks today. read more:

Agios Pharmaceuticals, Inc. (symbol: AGIO) was one of the worst losers of
the trading day today (2015-12-07), losing -20.41%. The number of shares
that changed hands was 1,670,218, or about 3 times the average daily volume
in the stock.
The closing price was $49.26, amounting to a market cap of $1,850,000,000,
about -64.52% off the highest price in the last 12 months. The stock has
been trading at a range between $48.0 and $138.85.
AGIO is in the Major Pharmaceuticals industry, part of the Health Care
sector. It first went public in 2013.