$ISIS is one of biggest winner #stocks today. read more:

Isis Pharmaceuticals, Inc. (symbol: ISIS) was one of the biggest winners of
the trading day today (2015-10-27), gaining 11.35%. The number of shares
that changed hands was 2,600,930, or about 1.4 times the average daily
volume in the stock.
The closing price was $51.9, amounting to a market cap of $6,230,000,000,
about -33.29% off the highest price in the last 12 months. The stock has
been trading at a range between $37.38 and $77.8.
ISIS is in the Major Pharmaceuticals industry, part of the Health Care
sector. It first went public in 1991.
Looking at its valuation, the stock is now trading at 273.16 times earnings.